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761 The overexpression of CYP1B1 increases the ubiquitination and degradation of ACSL4, and melatonin could inhibit ferroptosis by regulating the ACSL4/CYP1B1 pathway, significantly reducing the cerebral ischemic area and neuron loss in MCAO mice

The use of the Nrf2 activator oltipraz effectively inhibits the expression of transferrin receptor (TFR) and divalent metal transporter (DMT1), which in turn suppresses ferroptosis and alleviates depressive symptoms (Zeng et al., 2023)

& Pamme, N

Mutat Res 428:299304

VanItallie, T
