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4.3 Kidney-heart crosstalk The cardiorenal interaction plays a pivotal role in cardiovascular pathophysiology, classically exemplified by cardiorenal syndrome (CRS), where dysfunction of either the heart or kidneys triggers secondary injury in the other organ through neurohumoral regulation, hemodynamic alterations, and inflammatory responses (Ronco et al., 2010)

However, it is crucial to keep in mind that if, at the end of corticosteroid and antiviral treatment, symptoms reappear with a decrease in ACTH levels, this could indicate potentially permanent pituitary damage (pituitary atrophy) (245, 246)

Therefore, antioxidant therapies aimed at reducing oxidative stress represent a promising approach for protecting the BBB and mitigating cognitive decline (Rochfort et al., 2014)

CC-chemokine activation in acute pancreatitis: enhanced release of monocyte chemoattractant protein-1 in patients with local and systemic complications
