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IGF-1 elevation led to the accumulation of FOXO3A in the cytosol of prostate tumor cells and downregulation of its target gene Bim , which resulted in the apoptosis inhibition and prostate cancer overgrowth

The duration effect suggests GHK-Cu induces cumulative structural changes in dermal architecture where longer treatment allows more complete remodeling supporting ongoing enhanced function without continuous peptide presence

Staining in shoot was much lower and only restricted to leaf tip for NBT ( Supplemental Figure 2C )

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Although various hormonal therapies and surgical treatments are available, their long-term effectiveness is limited, recurrence rates are high, and side effects are significant