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MarkovicJMoraNJBrosetaAMGimenoAde-la-ConcepcinNViaJet alThe depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts

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When growth hormone then interacts with these upregulated receptors, it produces a dose-dependent and time-dependent increase in cell proliferation

True neuroadaptation may also contribute, though the time course and reversibility suggest these adaptations remain relatively modest