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Gastrointestinal effects dominate: nausea (1722%), diarrhea (1316%), vomiting (610%), decreased appetite (79%), and indigestion (~7%)

These were in the cerebellum (ibuprofen [238], paracetamol [239]), the cerebral cortex (diclofenac [240,241], celecoxib [201]), the frontoparietal cortex (concussive brain trauma) [231], the hippocampus and the cerebral cortex (insulin) [242], and the parietal neocortex and the hippocampus (cuprizone [232])

Glucagon A hormone that raises blood sugar by signaling the liver to release stored glucose

Cycling and breaks Given the unknowns about long-term continuous use, many researchers implement cycling protocols

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