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Serum copper rises naturally during pregnancy as oestrogen drives an increase in ceruloplasmin, the protein that transports copper in the blood, and one 2007 study found that women with a history of postpartum depression had somewhat higher serum copper on average than women without that history
For a 100kg individual, that translates to 22.5kg lost versus 2.4kg
Notably, studies have shown that knocking down NNMT in adipose tissues and livers of mice fed a high-fat diet resulted in decreased serum TG and FFA levels (Zhu et al., 2016)
