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Laferrre et al (149) reported decreased BCAA, CRP and IL-6 levels after gastric bypass surgery, yet the small sample size and the physiological changes induced by surgery limit the generalizability of these findings

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Similarly, mice fed a high-Met, low-folate and low-vitamin B12 diet (1.2%, 0.08 mg per kg of diet, and 0.01 mg/kg per kg of diet, respectively, for 16 weeks) developed HHcy and, as a consequence, endothelial hyperpermeability in cerebral vessels

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