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24-week continuous: Mirrors the longest human trial duration

What the evidence really shows This is the key part: when AOD-9604 was tested in human weight-loss trials, the results largely did NOT show a strong effect

Hence the need for loading doses

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss