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Description
BRCA1, which regulates cell cycle progression, DNA damage signalling and repair, and maintenance of genomic integrity, interacts with NRF2 either directly, through its ETGE motif, preventing KEAP1-dependent ubiquitination of NRF2 and protecting cells against OS, or indirectly, through the interaction with CBP or with c-Myc [186]
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Previous studies focused on tauopathies, -synuclein accumulation (Zhang et al., 2018
The ability of glutathione to detoxify heavy metals, toxins, and free radicals is vital in supporting overall cellular health
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