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Still, these side effects can be mitigated by introducing the compound slowly, applying it every other day, or using a lower concentration of the active ingredient

evidence is limited to Phase 2 and individual results vary

Elderly patients on long-term PPIs should have their B12 status monitored periodically and may require injectable B12 if deficiency develops

The compounds quinolinium scaffold confers membrane permeability that enables intracellular enzyme inhibition, distinguishing it from earlier polar NNMT inhibitor scaffolds that did not effectively enter intact cells