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Acknowledgements The authors are grateful to the research assistants of Biology Department of Arak University and also the members of Roya Infertility Center in Qom for their support and cooperation throughout this research

For example, ketoconazole, an inhibitor of CYP3A4, inhibited the formation of desethylchloroquine by 33 % and 45 % at concentrations of 1 10 6 and 1 10 5 M/L, respectively [93]

Nat Commun (2017) 8, 2255

In the presence of BSO the accumulation of a small capsid precusor (pentamer) is reduced and consequently no mature viruses are produced in virus-infected cells