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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Kim J.S., Choi Y.J., Woo M.R., Cheon S., Ji S.H., Im D., et al
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10.3389/fneur.2018.00640 42 KontosH
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For instance, HMGB1 can regulate calcium levels through a TLR4/ROS-dependent pathway, leading to calcium leakage from the sarcoplasmic reticulum, a reduction in the amplitude of calcium transients, and decreased cardiomyocyte contractility, which can further aggravate the pathological processes in the heart [307]
