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Hypoxia tends to maintain the levels of Hypoxia Inducible Factor (HIF-1), which regulates numerous cellular processes, including angiogenesis and proliferation, and as a result, can cause delayed wound healing ( Extracellular matrix The Extracellular matrix is a key environmental component in healing diabetic wounds, as it acts as a dynamic scaffold for cells and facilitates tissue development and regeneration ( Figure 2 )

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The usefulness of forced diuresis is not established

Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion

Its levels increase during inflammation and initiate coagulation mechanisms when vascular injury occurs