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Additionally, Fe2+ binds to the N-terminal domain of A, destabilizing its helical structure and promoting peptide aggregation by enhancing peptide-peptide interactions (37)

In this study, by establishing and utilizing a revSC-rich organoid culture system, together with detailed isolation of defined cell populations by FACS, we provide experimental evidence demonstrating the high fetal reversion potential of CBCs and the bidirectional interconversion between CBCs and revSCs

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