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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

Ideally, blood tests (including full blood count, serum B12, folate, and possibly anti-intrinsic factor antibodies if pernicious anaemia is suspected) should be performed before starting supplements, as supplementation can affect test results

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Advertisement Article continues below this ad Gastrointestinal Reactions A common question people have when they are prescribed vitamin B12 injections is can B12 shots make you sick