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Another study found that paclitaxel induced significant upregulation in IL-1, IL-1, IL-6, TNF-, INF- and MCP-1, which was attenuated by a TNF-alpha monoclonal antibody (etanercept) [1] In a vincristine CIPN model, the anti-inflammatory cytokine, IL-4, and associated STAT signalling was reduced, with an increase in pro-inflammatory cytokines such as IL-1-beta and TNF-alpha[92]

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It has become the most commonly used intravenous anesthetic due to its favorable pharmacokinetic and pharmacodynamic profile [125,126]

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