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Increased BBB permeability permits the entry of inflammatory cytokines, LPS, and other neurotoxic chemicals that can induce or worsen neuroinflammatory responses, further affecting brain function

Thus, the intake of B12 through the diet should be significantly higher, since not all B12 from the diet can actually be absorbed

It increases the Nrf2-Keap1-antioxidant response element (ARE), which helps maintain healthy anti-inflammatory, antioxidant, detoxification and autophagy actions

Mechanistically, dietary MR was found to downregulate proprotein convertase subtilisin/kexin type 9 (PCSK9), a negative regulator of MHC-I expression and TCR signaling, through inhibition of DNA methylation (116)

Milk thistle extract contains an antioxidant and an anti-inflammatory called silymarin that has been shown to help ease inflammation and promote cell repair within the liver