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Carnitine/acetylcarnitine also have potentially positive effects on hormonal and metabolic parameters in patients with reproductive dysfunction, such as polycystic ovary syndrome [86, 87], and these effects may involve a series of complex signal transduction pathways to maintain the homeostasis of the endocrine system [88]

The fraction of Lcarnitine excreted unchanged in urine was 0.730.95, suggesting that although renal reabsorption of Lcarnitine is very efficient at physiological concentrations, renal transporters become saturated at the high concentrations achieved with IV dosing resulting in extensive renal excretion

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doi: 10.1111/j.1472-8206.2010.00888.x

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