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In the peripheral circulation, calcium channel blockers also produce a reduction in total peripheral resistance, with an associated decrease in blood pressure & afterload

The NADH produced can interfere with the mitochondrial electron transfer system producing ROS [138,139]

This upregulation of GAS5 inhibits ULK1-driven autophagy initiation, thereby suppressing the growth and metastasis of NSCLC cells in vitro and in a subcutaneous tumour model [188]

Elevated pO 2 in the alveoli drive an increase in dissolved O 2 concentrations in blood, and this is rapidly communicated to all internal organs where it can cause oxidative damage and disrupt cell signaling processes

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