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Or, the glutamate can be further converted to GABA using the GAD1 enzyme, which requires the active form of vitamin B6 (P5P) as a cofactor.[ref] Genetic variants that reduce the conversion of B6 to its active form, P5P, could therefore impact GABA synthesis and GABAergic neurons

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Peer review Peer review information Nature Reviews Endocrinology thanks Trond Michelsen, Ye Yuan and the other, anonymous, reviewer(s) for their contribution to the peer review of this work