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61% of patients have reported being bedbound on their worst days (41) and at least one-quarter of ME/CFS patients have recounted being housebound or bedbound at some point in their lives (2)

and colorectal cancer screening adherence among diverse immigrants J Cancer Policy doi: 10.1016/j.jcpo.2024.100516 Buckner Petty SA, Raynor G, Verdiner R, Stephens EH, Oboh O, Williams T, Shore-Lesserson L, Milam AJ

However, for those who wish to lighten existing spots, several options are available

PubMed Central PMCID: PMC3508147

In this procedure, which is performed under general anesthesia, the affected limb is surgically isolated from the rest of the body with a bypass system