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If you experience symptoms of a severe allergic reaction (breathing difficulties, facial swelling, widespread rash, dizziness) after taking B12, seek emergency medical attention immediately

[DOI] [PubMed] [Google Scholar] Hench PS, Kendall EC, Slocumb CH, Polley HF

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The FDA explains that compounded drugs are not FDA-approved , meaning the agency does not verify their safety, effectiveness, or quality before marketing (see Compounding and the FDA: Questions and Answers )