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Hunt, K.A

AGS cellular models were associated with accumulation of glutathione (GSH), a ROS scavenger indicative of oxidative stress 37 , and TCA feeding metabolite glutamate (GLU) (figure S7F right panel )

doi: 10.3390/molecules17043609, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Gao Q, Killie MK, Chen H, Jiang R, Seljelid R

10.7150/thno.16844 97 YangX.ChangY.WeiW

Free radicals play critical role in generating oxidative stress, which oxidizes dopamine to dopamine quinone and superoxide anion and decreases the NADPH and dopamine metabolized by MOA that produces the 3,4-dihydroxyphenylacetaldehyde, ammonia, and H 2 O 2 , which in turn interacts with Fe ++ to generates the OH free radicals that kill neurons in PD [61, 62]
