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5-FU administration contributes to oxidative stress, leading to peroxidation, oxidation, and cross-linking of membrane lipids, proteins, and cellular thiols, leading to the formation of malondialdehyde, ROS, hydroxyl radicals, superoxide anions, and so forth

[DOI] [PMC free article] [PubMed] 16.Xu YX, Liu LD, Zhu JY, et al

Vitamin K-dependent proteins such as osteocalcin and matrix Gla protein are crucial to many physiological processes such as bone mineralization, vascular calcification, and cardiovascular health

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Rodrguez-Yoldi M.J

Before bed: this is the most impactful time you can take electrolytes whilst drinking