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PMID: 29114614

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To express and purify the recombinant protein of F0726_RS04210, the coding sequence was amplified using primers F- gr and R- gr

However, therapeutic strategies targeting apoptotic pathways have yielded mixed results, and many patients exhibit primary non-response to current standards of care, such as anti-TNF agents and JAK inhibitors [5,6,7]

Although both cGPX4 and mGPX4 can inhibit ferroptosis under different conditions [45,85], the first evidence that gpx4 gene deletion induces ferroptosis was reported after an induced disruption of GPX4 in mouse embryonic fibroblast cells (also known as Pfa1 cells) [21]