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Acknowledgements The current work was supported by the Chinese National Natural Science Fund (31925013, 32125016, T2321005, U20A20393, 32070907, 31871405, 31870902, W2411011 and U24A20371), a special program of the Ministry of Science and Technology of China (2024YFC2707400, 2021YFA1101000, 2022YFA1105200 and 2023YFA1800200), a Key Research and Development Program of Zhejiang Province (2024C03142), a joint project of the Pinnacle Disciplinary Group, the Second Affiliated Hospital of Chongqing Medical University, the Science Foundation of Jiangsu Province (19KJA550003), the Suzhou Innovation and Entrepreneurship Leading Talent Program (ZXL2022505), a Suzhou Medical College Basic Frontier Innovation cross-research project (YXY2303027), key cross-research projects of the School of Medicine at Soochow University (YXY2303027) and the Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases

8 May help reduce damage to the liver Just like any other cell In the body, liver cells require high levels of antioxidants especially glutathione

659 The level of GPX4 in the brain gradually decreases after TBI, and overexpression of GPX4 can partially reverse TBI-induced hippocampal ferroptosis and synaptic damage, effectively alleviating neuronal dysfunction after cerebral hemorrhage, and improving TBI-induced cognitive deficits