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Subgroup analysis showed an ORR of 20% and a median progression-free survival (PFS) of 3.9 months in melanoma patients with positive intratumoral RIPK3 expression (IHC score 2+), while no objective responses were observed in RIPK3-negative patients, validating RIPK3 as a predictive biomarker for necroptosis-targeted therapy

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The ferric cyanide reducing potential assay identifies the presence of reducing agents in extracts by donating electrons to convert ferricyanide (Fe 3+ ) to ferrocyanide (Fe 2+ ), resulting in a color shift that can be detected using a spectrophotometer 66

A clinical trial involving 56 women demonstrated that PEA treatment at 300 mg/day for 6 months not only relieved pain but also improved sexual function and enhanced overall quality of life