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This aligns with the mechanistic literature

Introduction Tuberculosis (TB), a communicable disease caused by Mycobacterium tuberculosis (Mtb), remains a major public health challenge ( Intracellular glutathione (GSH) level has been pointed as an important biomarker in HIV infection ( Besides NAC effects on Mtb growth, several studies have suggested this drug as an important modulator of host cell biology and immune response ( Recently, we have reported a clinical trial conducted with hospitalized HIV/TB patients in Brazil in which we evaluated the safety of NAC and its efficacy in accelerating mycobacterial clearance in sputum cultures ( Methods Ethics Statement The study was approved by the Ethics Review Committee of Fundao de Medicina Tropical Dr Heitor Vieira Dourado (FMT-HVD) (protocol study number: 60219916.5.0000.0005)

Based on these findings, short-term use of amitriptyline or duloxetine was recommended

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Its downregulation may impair cellular stress management, promoting protein aggregation and cellular dysfunction, which contribute to PEXS pathogenesis (Hayat et al., 2020)