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Others have shown that deleting the linker of PLC3 increases basal activity and this construct cannot be further activated by G q (Lyon et al., 2013), but here we demonstrate that PLC2 with the CTD-linker deleted did not respond to either heterotrimeric G-protein, suggesting that movement of the distal CTD is important for activation by both G-proteins

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Try to do at least 150 minutes of these exercises each week