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Curcumin is often described as a hormetic compound because it induces an adaptive stress response: it mildly stresses cells in ways that activate Nrf2 and other transcription factors, leading to increased production of antioxidant and cytoprotective proteins (e.g., heme oxygenase-1) that precondition cells against subsequent injuries (77, 78)

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Currently, the approved EZH2 inhibitors include tazemetostat and valemetostat (approved only in Japan), while other drugs in clinical trials include GSK126, CPI-1205, SHR2554, and PF-06821497 [189]