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563 Monitoring and considerations include dose titration, initiating medications at low doses and gradually increasing to the maximum tolerated dose while monitoring efficacy and adverse effects

D'Andrea '14, G'16 Joseph George Daniel '12 Colleen M

doi: 10.3390/cancers11030317 31 ZhangDLiJWangFHuJWangSSunY

Results Contractile recovery following metabolic inhibition is reduced but cell survival is unaffected by TMAO Given the association of high TMAO concentrations in the blood and the incidence of cardiac disturbance in patients, it was hypothesised that increasing concentrations of TMAO would worsen the outcome for cardiac cells in a widely used metabolic inhibition and simulated reperfusion (MI/R) model (Figure 1A) (Brennan et al., 2019