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Polymicrobial presence (bioburden) has been well documented in chronic wounds and can play a major role in impaired wound healing, even in the absence of clinical signs of infection (Fig

In the last years, several reports have shown that sublethal concentrations of ROS trigger a retrograde response that not only increases lifespan in different animal models, from worms to mammals, but also enhances healthspan, particularly improving metabolism and immune system 51,71,72,73

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