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Inconsistent depth means inconsistent absorption, which means inconsistent results week to week

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When deficiency is diagnosed, lifelong B replacement is often required (especially in pernicious anemia)

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The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison
