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It is ubiquitously expressed in the heart, skeletal muscle, kidneys, and intestine

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doi: 10.1016/j.jamda.2020.06.018

Bibcode:2002PNAS...99.2356L

Intermittent claudication in peripheral arterial disease In peripheral arterial disease, atherosclerosis of the arteries that supply the lower extremities may diminish blood flow to the point that the metabolic needs of exercising muscles are not sufficiently met, thereby leading to ischemic leg or hip pain known as claudication (see the page on Intermittent Claudication in Peripheral Arterial Disease) (63)