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Histone tail acetylation is believed to enhance the accessibility of a gene to the transcription machinery, whereas deacetylated tails are highly charged and believed to be tightly associated with the DNA backbone, thus limiting accessibility of genes to transcription factors [4]

Measurement of GABA levels in vivo by means of MRS offers the possibility to approach the illness from a unique perspective and provides additional insights in the relationship between deficit components of GABA neurotransmission and GABA-mediated inhibitory activity