pdb glutathione s transferase uniprot RCSB RCSB PDB - 1AQW: GLUTATHIONE

Whats Inside (and Why It Matters)

With the synthetic lethality and druggability constraints together yielding only 8 double gene deletions, an FVA constraint was not applied in the search for high-priority synthetic lethal targets

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Fluge ., et al

Mol Cell Biochem 303:4551 Dasuri K, Zhang L, Keller JN (2013) Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis

Both peroxyl radicals and alkoxyl radicals are further cyclized and dependent on the type of polyunsaturated fatty acid, degraded into reactive aldehydes such as 4-hydroxynonenal (4-HNE) or malondialdehyde (MDA) (Fig