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Heparin nanocarrier loaded with cisplatin and Olaparib downregulates MRP-2 and P-gp resulting in intracellular accumulation of cisplatin and Olaparib causing downregulation of PI3K/AKT/mTOR signaling pathway which enhances the anti-proliferation of cisplatin against CR OC [61]
In addition, - and -tocopherols more effectively activate peroxisome proliferator-activated receptor gamma (PPAR) than -tocopherol and can prevent tumorigenesis [98]
If the temperature change to the heart is rapid, ventricular fibrillation may result
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10.1038/s41598-025-00164-6
