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Oncometabolites such as fumarate, D-2-hydroxyglutarate and succinate accumulate in tumors and regulate epigenetic changes [69]
Its anti-inflammatory mechanisms involve modulating cellular signaling pathways, including suppressing NF-B activation, a critical inflammatory transcription factor [5]
doi: 10.1016/j.ccell.2014.11.019
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e.g., a shorter-than-expected phase will result in much shorter hair, and a longer phase will result in long hair
