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The classic motor symptoms of PD result from selective degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in a loss of their long axonal projections to the striatum

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At the cellular level, 5-amino-1MQ orchestrates a complex rebalancing of fundamental metabolic processes through its effects on the NAD+ salvage pathway and one-carbon metabolism

Elderly patients tend to have a greater frequency of decreased hepatic, renal, or cardiac function, and also have concomitant disease or receiving other drug therapy