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Pathophysiologically, RDN not only decreases systemic sympathetic tone but can also be implicated in renal protection, opposing the evolution of hypertensive nephropathy by correcting renal hemodynamics and reducing glomerular hyperfiltration [196]

Regarding association studies between the GPX1 rs1050450 Pro198Leu variant and stroke, two published studies, one in Finnish/Swedish subjects and one in Turkish subjects, reported that there was no association of the GPX1 rs1050450 Pro198Leu variant and risk of stroke [111, 112]