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Moreover, HO-1 is also upregulated in the heart under these pathological conditions
Drose et al., 2013a)
Third, fasting state and age are not perfectly controlled, and there is variability in blood processing time and time of blood collection following diagnosis
By unregulating Notch and p53 signaling pathways and secreting matrix metalloproteinases (MMPs), growth factors, and cytokines, they stimulate angiogenesis, inflammatory response, cell proliferation, and invasion (67, 68)
doi: 10.3389/fgene.2012.00007
