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For a supplement to be effective, it needs to bypass the destructive environment of the stomach and the "first-pass metabolism" of the liver

Prognosis is better if, in addition to radical surgery, further therapeutic options such as radiotherapy (Cronin et al., 1998

This result laid the foundation for developing RNA double-stranded drugs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs)

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