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Biol Trace Elem Res 24:109117 Mischley LK, Conley KE, Shankland EG, Kavanagh TJ, Rosenfeld ME, Duda JE, White CC, Wilbur TK, De La Torre PU, Padowski JM (2016) Central nervous system uptake of intranasal glutathione in Parkinson's disease

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GSR: The Recycling Engine GSR (glutathione reductase) catalyzes the NADPH-dependent reduction of GSSG back to two molecules of GSH the recycling step that sustains the GSH pool without requiring de novo synthesis from amino acids

Beneficial effect of alpha-lipoic acid on lipopolysaccharide-induced oxidative stress in bronchoalveolar lavage fluid

This ideally positioned melatonin as a radical scavenger since the process of oxidative phosphorylation in mitochondria is the site of the production of the superoxide anion radical, the precursor of all other destructive ROS as well as reactive nitrogen species (RNS) ( Figure 3 )