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These complications notwithstanding, the potential upside of identifying clinically useful AQP4 inhibitors is promising and should inspire further studies and clinical trials

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Functioning as a potent exercise mimetic, this small-molecule compound enhances mitochondrial function, fatty acid oxidation, and oxidative muscle fiber composition, thereby improving exercise endurance, cardiac metabolic efficiency, and systemic energy expenditure without increasing food intake 1-4

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Various assays and techniques were employed to assess macrophage polarization, such as gene expression analysis, cytokine secretion profiling, and surface marker analysis