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Third, they found that the enzymatic activity of NNMT is necessary for the increase in Sirt1 protein expression and a product of NNMT (MNA) plays a key role [14]

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Among these patients, 3 experienced disease progression (PD) during the first treatment cycle, 2 had stable disease, and 2 developed PD after having achieved response (1 partial response [PR] and 1 very good partial response [VGPR]) (57)

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