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"Genetics are often the primary driver of premature graying but environment and lifestyle factors also play a role and can accelerate it." While optimizing glutathione and antioxidant levels can help, Lee said it won't compensate for systemic poor health including smoking, high alcohol intake and processed food-heavy diets
10.1186/s12979-018-0128-5 39 ZhongW.SuW.LiT.TanX.ChenC.WangQ.et al (2021)

Personally, I find solace in adaptogens like ashwagandha and rhodiola, which play a role in balancing cortisol levels

However, the enhancement of antioxidants defense or improvement of mitochondrial enzymes activities can be a useful tool for improving oxidative stress-related renal failure (Table 1)