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Skin rejuvenation is the gentlest target

[DOI] [PMC free article] [PubMed] [Google Scholar] Smith AD, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A et al (2018)

Mice with enhanced GH signaling but deficient in STAT5 show increased susceptibility to hepatic steatosis and hepatocellular carcinoma, demonstrating the importance of this pathway in maintaining liver health

besides, the combination of lycopene with vitamin E might achieve better outcome, so the combined application of lycopene with other strategies are warranted to be confirmed in more well-designed RCTs
