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In the context of liquid biopsy, biomarkers reflecting peripheral iron homeostasissuch as CSF ferritin and the serum sTfR/ferritin ratiohave demonstrated high sensitivity and specificity in distinguishing mild cognitive impairment (MCI) from AD (Du et al., 2024)

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This system has received considerable research attention related to its role in solid tumor cancers and possible therapies [75-77]

doi: 10.1038/tp.2014.52