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[3] [4] According to the MHRA-approved Summary of Product Characteristics, the formulation also contains several inactive excipients that serve specific pharmaceutical purposes: Disodium phosphate dihydrate provides buffering capacity to maintain pH stability Propylene glycol acts as a co-solvent and stabilising agent Phenol functions as an antimicrobial preservative Water for injections serves as the vehicle for the solution Hydrochloric acid and/or sodium hydroxide may be used for pH adjustment These excipients are standard pharmaceutical ingredients used in injectable medications and are present in carefully controlled quantities to ensure product stability, sterility, and patient safety

10.1136/bmjopen-2013-004501 28 JadadA

Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration

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