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Lipid-OOHs are unstable, and can be broken down to reactive compounds like malonaldehyde, hexanal, and 4-hydroxynonenal, etc., which are capable of serving as oxidative stress second messengers because of their longed half-life and ability to diffuse from their formation site [30, 31]

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Anand U, Bandyopadhyay A, Jha NK, Prez de la Lastra JM, Dey A: Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate

Moreover, properly harnessing the Nrf2/HO-1 axis while managing its potential pro-ferroptotic risks may help maintain redox balance and curb iron overload, thereby offering an additional strategy to alleviate ferroptosis-driven damage in OA (202)

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Similarly, aberrant labeling observed in PEG-repaired animals may in part reflect compensatory, intraspinal sprouting from terminal afferent projections into denervated afferent fields, similar to the intracortical sprouting seen after trauma to the forelimb (Florence et al., 1998)